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Michigan State University Student Radio

Impact 89FM | WDBM-FM

Michigan State University Student Radio

Impact 89FM | WDBM-FM

Michigan State University Student Radio

Impact 89FM | WDBM-FM

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The Sci-Files – 07/23/2023 – Brett Volmert – Growing Mini Human Hearts from Stem Cells

Brett Volmert

On this week’s The Sci-Files, your hosts Chelsie and Danny interview Brett Volment. Heart diseases represent the leading causes of death worldwide. Researchers commonly use cellular and animal models to investigate and study cardiovascular disease and other diseases. However, these models do not provide the best representation of human physiology. To this end, Brett’s work focuses on growing and creating miniature 3D human hearts, termed “heart organoids” that allow more faithful insight toward heart development, disease mechanisms and effective treatments for heart disease. Brett creates these mini hearts using human stem cells and mimics the environment present in the fetus to advance their maturity. In doing so, he elicits 3D hearts with all major cell types found in the human heart, internal chambers representing atria and ventricles, and a dynamic vessel network. This system represents a powerful tool that researchers can use to investigate human heart development and to screen for disease therapeutics, and ultimately, serves as a major stepping stone towards generating fully synthetic human hearts from stem cells.

If you’re interested in talking about your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on TwitterFacebookInstagram, and YouTube!

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About the Contributors
Chelsie Boodoo, The Sci-Files Host
Chelsie is a Biomedical Engineering Ph.D. student at Michigan State University. She studies what happens to the extracellular matrix of cells after they have been stressed. She co-hosts "The Sci-Files" with Daniel Puentes. Together they explore the different topics that MSU students research on "The Sci-Files" at WDBM.
Daniel Puentes, The Sci-Files Host
Daniel is a graduate student in the Department of Physics and Astronomy, where he does research at the National Superconducting Cyclotron Laboratory. His research involves measuring the mass of radioactive nuclei, and how it can tell us how protons and neutrons are arranged inside of a nucleus. This research also helps scientists understand how the elements were created in different stellar environments! At WDBM, he and Chelsie Boodoo co-host The Sci-Files.

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