The Sci-Files – 06/19/2022 – Zach Miller – Cancer Cell Line Therapeutic Window Evaluation

Chelsie Boodoo and Daniel Puentes

Zach Miller
Zach Miller

On this week’s SciFiles, your hosts Chelsie and Daniel interview Zach Miller. A therapeutic window is a dose range between the minimum effective drug dose (MED) to the minimum toxic drug dose (MTD). Many commonly-used cancer drugs, including chemotherapies such as Doxorubicin, are highly toxic to normal tissues and have narrow therapeutic windows. The drug concentration should constantly remain between the MED and MTD in order to produce risk-free therapeutic effects. In general, critically, administration of too much drug (above the therapeutic window) will cause serious side effects on normal human organs, leading to patient morbidity or even death. On the other hand, too little drug (below the therapeutic window) will result in a lack of treatment efficacy and may induce cancer drug resistance, which is the most important reason for the failure of chemotherapy. Herein, we studied the viability of two cell lines, a dox-sensitive cell line (BT459) and a non-dox-sensitive cell line (4T1), to estimate the therapeutic window of doxorubicin. We studied the cell viability to estimate the therapeutic window of DOX in vitro so as to guide the DOX dose in vivo.
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