fbpx
Michigan State University Student Radio

Impact 89FM | WDBM-FM

Michigan State University Student Radio

Impact 89FM | WDBM-FM

Michigan State University Student Radio

Impact 89FM | WDBM-FM

join-us-button

The Sci-Files – 2/4/2024 – Logan Soule – Blood Storage: Even Red Blood Cells Get a Sugar Crash

On this week’s episode of The Sci-Files, your hosts Mari and Dimitri interview Logan Soule. Blood transfusions can be life-saving procedures for patients in need. However, they can also impart much more devastating complications, leading to poorer outcomes than prior to transfusion, such as infection, inflammation, and even death. This is in part due to the red blood cell “storage lesion”, which refers to the irreversible metabolic and physiological damages that occur to red blood cells (RBCs) during their storage period, such as membrane damage, protein/lipid oxidation, glycation, cell lysis, and many other detrimental changes vital to proper RBC function.

Logan Soule is a 5th year PhD candidate in the Department of Biomedical Engineering. Logan’s work focuses on attempts to alleviate the development of the storage lesion. His lab believes that a culprit behind these damages is the significantly high sugar content in RBC preservatives, which is 8x higher than diabetic patients. His work highlights the benefits of storing RBCs at physiological glucose levels, leading to exceptionally better RBC functionality than traditional hyperglycemic storage. However, normoglycemic storage requires “feeding” the cells with a concentrated glucose solution as the RBCs metabolize the glucose, limiting this technique’s application, until now. Logan has designed and implemented an automated glucose feeding device to successfully maintain normoglycemic conditions of stored RBCs. These findings implicate exciting changes in transfusion medicine that are more feasible than ever before. Storing blood under normoglycemic conditions is now not only possible but has significant potential to lead to better patient outcomes.

If you’re interested in discussing your MSU research on the radio or nominating a student, please email Mari and Dimitri at [email protected]. Check The Sci-Files out on Twitter and Instagram! 

 

Leave a Comment
More to Discover
About the Contributors
Mari Dowling
Mari Dowling, Sci-Files Producer and Co-Host
You can contact the Sci-Files hosts at: [email protected]
Dimitri Joseph
Dimitri Joseph, Co-Host of The Sci-Files
Dimitri is a 4th year D.O.-Phd (Pharmacology and Toxicology) student. He is currently in his second year of medical school. He started with Impact 89 FM as a volunteer DJ and is now a co-host of The Sci-Files. Outside of the rigors of the academic hustle, I enjoy consuming or creating a variety of art. "Remind yourself. Nobody is built like you, you designed yourself" - Jay Z

Comments (0)

All Impact 89FM | WDBM-FM Picks Reader Picks Sort: Newest